Telomerase Assay Using Radioisotopes.
نویسندگان
چکیده
منابع مشابه
Radioisotopes in Medicine
Nuclear medicine uses radiation to provide diagnostic information about the functioning of a person's specific organs, or to treat them. Diagnostic procedures are now routine.. Radiotherapy can be used to treat some medical conditions, especially cancer, using radiation to weaken or destroy particular targeted cells. Millions of nuclear medicine procedures are performed each year, and demand fo...
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BACKGROUND Recent studies have associated telomerase with prognostic factors and survival in neuroblastoma. PROCEDURE We examined telomerase activity by telomere repeat amplification protocol (TRAP) and expression of the RNA component of telomerase (hTR) by Northern blotting in 106 primary neuroblastoma tumors and 22 established cell lines. RESULTS Overall survival at 5 years for all 106 tu...
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Nanomedicine, the medical application of nanotechnology, is poised to make a major impact on the diagnosis and treatment of many diseases. It is a relatively new branch of science that involves harnessing the unique properties of particles that are nanometers in scale (nanoparticles) for both diagnostic and therapeutic applications. Nanoparticles (NPs) can be engineered with precise sizes, shap...
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BACKGROUND While telomerase is undetectable in most normal somatic tissues, telomerase activation has been detected in many immortal cell lines and various cancers. AIM To investigate telomerase expression in hepatocellular carcinoma, and to assess the expression of the RNA component of telomerase, hTR. METHODS 39 hepatocellular carcinomas were studied using a telomerase polymerase chain re...
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Human telomerase, a ribonucleoprotein enzyme is known to be associated with immortalized cancer cells but is absent in most normal tissues. Thus, telomerase appears to be an attractive new target for anticancer agents and an important diagnostic marker of human cancers. Here, we describe an improved telomerase assay method based on the Dynabead biomagnetic separation theory. In this method, 5'-...
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ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 1998
ISSN: 1884-4111,0033-8303
DOI: 10.3769/radioisotopes.47.12_985